Tüm ürünler

Applikon BioSep

Name: Applikon BioSep
Brand: Getinge

Scalable cell culture perfusion

The Applikon BioSep is a unique cell retention device for the process of constant feeding of fresh media and removal of spent media, while retaining a high number of viable cells. It uses high frequency resonant ultrasonic waves to separate cells and thereby automatically removes cell debris, which makes it the perfect solution for continuous bioprocesses.

Your interest in bioreactor systems

Country Selector

The Applikon BioSep 50 liter perfusion device

The Applikon BioSep 10 liter perfusion device

The Applikon BioSep 1 liter perfusion device

The ideal solution for long-term cultivation

Automatic removal of cell debris
No damage to the cells
No fouling or blocking allows for long term operation
Scalable perfusion device (0,1 – 1.000 L / day)

High separation efficiency

Using the technology of acoustic resonance allows for high separation efficiency (99%) without damaging any cells. One standard mode of operation employs, for example, a harvest pump at the exit port of the resonator chamber, and a recirculation pump for the return of separated cells that settled from the acoustic energy field within the resonator chamber. Alternatively, the Applikon BioSep system can be set up to allow for semicontinuous operation or alternative strategies of cell recirculation.

Easy to install and operate

The Applikon BioSep can be mounted directly onto the bioreactor head plate. An extensive characterization has proven full scalability between the different sizes allowing you to start in perfusion mode directly at the beginning of your process optimization all the way through to production.
The Applikon BioSep system is available in 1 L/day, 10 L/day, 50 L/day, 200 L/day and 1000 L/day and is compatible with any brand of bioreactor.

Proven under cGMP conditions

The Applikon BioSep system is used as perfusion device in various commercially operated cGMP processes. The 50 L/day and 200 L/day separation model are by default supplied with all documentation and services required for cGMP operation.

Specifications

BioSep system	1L	10L	50L	200L	1000L
Maximum perfusion rate	1 L/day	7 L/day	45 L/day	200 L/day	1000 L/day
Minimum perfusion rate	0.1 L/day	0.7 L/day	4.5 L/day	20 L/day	100 L/day
Separation efficiency	Up to 99% (depending on cell concentration and perfusion flow)
Minimum cell concentration	2 x 105 cells/ml (depending on cell size)
Bioreactor connection	6 mm OD tube	12 mm OD tube	Mounted separately	Mounted separately	Mounted separately
Medium inlet	3 mm hosebarb	6 mm hosebarb	10 mm hosebarb	0.5” TC	0.5” TC
Return line to bioreactor	3 mm hosebarb	6 mm OD diptube	0.5” TC	0.5” TC	0.5” TC
Perfusion outlet	3 mm hosebarb	6 mm hosebarb	6 mm hosebarb	0.5” TC	0.5” TC
Weight	0.1 kg	0.5 kg	1.5 kg	13 kg	70 kg
Resonator volume	0.7 ml	7 ml	50 ml	290 ml	1450 ml

BioSep Controller	APS 995	APS 990	APS 990	APS 992	APS 993
BioSep Controller Power	15 Watt	150 Watt	150 Watt	350 Watt	1500 Watt
BioSep Controller Dimensions (DxWxH, mm)	Combined with my-Control	305x130x130	305x130x130	450x400x135	450x300x450
BioSep Controller Weight (kg)	Combined with my-Control	3.5	3.5	17.6	43

The Applikon BioSep is ideal the for following applications:

Perfusion cultures
Concentration of cell / particles
Process development studies
Washing
First step in downstream processing

Marketing Sales - Sales Flyer

BioSep perfusion system flyer

Learn more about how to optimize your bioprocess by continuous perfusion

Applikon BioSep

Your interest in bioreactor systems

Applikon BioSep

The ideal solution for long-term cultivation

High separation efficiency

Easy to install and operate

Proven under cGMP conditions

Specifications

The Applikon BioSep is ideal the for following applications:

Marketing Sales - Sales Flyer

BioSep perfusion system flyer