- Resumen
- Características
- Applications
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pro-Control
Bioprocess control in Pilot and Production
- Fully configurable controller based on your requirements
- Turn-key package with the SUPR and the BioPilot / BioProduction
- Variety of software platforms available for maximum connectivity
The pro-Control can be integrated with the single-use production bioreactor (SUPR) in the range of 50 to 250 L maximum working volume, or with our stainless steel vessel with a range of 240 L (BioPilot) to 5,000 L (BioProduction) maximum working volume. The pro-Control is equipped with the latest standard in pump, MFC and sensor technology.
The pro-Control comes in two designs. One design is on wheels that provides optimal flexibility while working with the SUPR and the other design is placed on a skid next to a stainless steel bioreactor.
Seamless integration
The pro-Control integrates with any factory automation system, whether that is DeltaV (V-Control), Siemens PLC, Allen Bradley PLC or iFix. The pro-Control also offers a compatibility with a wide range of sensors, to ensure you can accurately measure your process.
cGMP compliant
This controller is ideal for usage in facilities with high-demanding GMP requirements. All components have carefully been selected for sterile working environments like biopharmaceutical production areas. The pro-Control can be used in a 21CFR part 11 compliant system.
Flexibility
The pro-Control can be used for both single-use and sterilizable-in-place applications at pilot and production scale. Whatever unique process requirements are being asked, we can create tailor-made systems matching these specific requirements.
Specifications
Sensors |
SUPR |
BioPilot / BioProduction |
|---|---|---|
| Single-use bioreactors | Stainless steel bioreactors | |
| pH Sensor | Mettler Toledo INSUS pH sensor | Traditional Electrochemical |
| DO sensor | Mettler Toledo INSUS DO sensor | Traditional Polarographic |
| Redox | No | Optional |
| Temperature | Pt-100, Measurement Range: 0-150 °C accuracy 0,1°C | |
| Foam/level | No | Resistive based measurement |
| Weight | Reactor load cells and balances | Reactor load cells and balances |
| Optional | Biomass (Capacitance or optical density), offgas measurements, pressure | |
| Additional I/O | Up to 8 Analog in and 4 Analog out | ConfigurableUp to 8 Digital in and 8 Digital out |
Actuators (optional) |
||
| Gas | Up to 8 MFC’s with solenoid valves or up to 8 rotameters with solenoid valves | |
| Liquids | Up to 4 internal fixed speed pumps | |
| Up to 2 external variable speed pumps | ||
| Impeller | Marine Impeller | Rushton, marine, hydrofoil and more |
| Temperature | Lauda Temperature Control Unit (TCU) | Cooling and heating jacket via bioreactor wall via tap water, chilled water, indirect steam or direct steam injection |
Control |
||
| Control Hardware and Software platform | Siemens or Allen Bradley Siemens, Allen Bradley, iFix, DeltaV™ | Siemens or Allen Bradley Siemens, Allen Bradley, iFix, DeltaV™ |
| Certifications | CE certified, GAMP compliant | CE certified, GAMP compliant |
| 21 CFR part 11 compatible | Yes | Yes |
| Communication & SCADA | Lucullus® PIMS, DeltaV™, iFix; Getinge OPC server available | Lucullus® PIMS, DeltaV™, iFix; Getinge OPC server available |
The pro-Control is ideal for the following applications:
- Microbial and cell culture
- Cell and gene therapy
- Cellular agriculture
- Screening studies
- Media optimization
- Process optimization
- Batch, Fed-Batch, Perfusion and Continuous cultivation