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Lucullus® PIMS
Complete data management for your bioprocess
- Optimize your workflow via the integrated planning tool and Design of Experiments module
- Combine all data, derived from various connected analytical devices, in one single software tool
- Connect multiple laboratories to a central database to simplify process data comparison
Data management and data analysis is key for the future of R&D and process development in the pharmaceutical industry. Lucullus® PIMS software allows the user to monitor and control bioprocesses and offers an extensive toolbox for analyzing process data across platforms. Process information can be gathered based on data generated in different brands of bioreactor types and in a wide range of different cultivation volumes. The combination of the software with the broad range of Getinge bioreactor systems offer the user a unique system for validatable fast track development and basic research.
One integrated software solution for the whole bioprocess workflow
One integrated software solution for the whole bioprocess workflow
Create your instruction sequences for simple or advanced processes and use them within multiple processes. Integrate sequential calculations in your instructions based on time and events. And receive notifications, emails, or SMS alarms in case your process deviates from your predefined limits.
Make optimal use of your shared resources using integrated scheduling tools. Maximize your experiment efficiency by integrating third party DOE modules into your planning process. Manage samples efficiently with overall strategies to coordinate sampling, sample tube preparation and barcoding. And retrieve data automatically from at-line analyzers.
Automate culture media creation and keep track of the availability of culture media in your storage. Optimize the availability of raw materials in your storage and get more insight by keeping track of raw media components used in your culture runs.
Execute a process based on a predefined recipe or planning. Start several bioreactors in parallel and monitor them simultaneously. Store process data in a safe and industry standard Oracle database and make well informed decisions by comparing multiple processes simultaneously. Evaluate running processes via 3D graphs and tables.
Visualize process results by creating advanced graphs and tables. Deepen your insight by using overlay graphs for a set of processes and turn data into useful information using advanced data analysis tools. Automatically verify your process model against your experimental data. Save time and achieve consistency by generating reports automatically.
Flexibility in architectures
Lucullus® PIMS can be supplied in three different architectures:
- Stand-alone edition
Used for up to 8 different bioreactors or one multi-bioreactor system on one computer. Access can occur via the local computer or via a remote network link to this computer - Client Server edition
Used for larger Lucullus® installations, when different labs use the software. Data can be stored in a safe location while front end user interfaces are located where they need to be, near the bioreactors - Enterprise edition
Used for even larger Lucullus® installations at different sites. Authorized users can view and compare data between different process development and / or production sites, even in different countries.
Parallel processing
The ever increasing amount of process data generated by more sensors in smaller parallel bioreactor systems needs advanced software to turn this data into useful information. Since all data is stored in one Oracle© database, Lucullus® saves the scientists time. No more need for data export and import between different solutions. Easily run multiple experiments in parallel and generate lots of data.
Digitalization
Lucullus® integrates all data from disparate sources into one platform. The digital warehouse simplifies information management, like sample and media management. It enables advanced process control and paperless documentation.
Specifications
Lucullus® Lite |
Lucullus® Standard |
Lucullus® Advanced |
Lucullus® Expert |
|
| General | ||||
| Operating system | Linux, Windows 7 (64-bit), Windows 10 | |||
| Communication drivers include | my-Control, in-Control, ez2-Control, i-Control, SUB-Control | |||
| Optional Controller drivers | no | Sartorius controllers, Eppendorf Controllers, NBS controllers, Infors Controllers, Siemens PLC, AMBR, Shaker/Incubators |
||
| Optional drivers for analytical instruments | no | Vicell, Nova Flex, Nove pHOx, Flownamics and more | ||
| Design of Experiments | no | no | yes | yes |
| Media preparation planning | no | no | no | yes |
| Analysis planning | no | no | no | yes |
| Resource planning (reactors) | no | no | yes | yes |
| Material Management | no | no | no | yes |
| Lot preparation | no | no | no | yes |
| Filling | no | no | no | yes |
| Storage management | no | no | no | yes |
| Data Acquisition | yes | yes | yes | yes |
| Process Control | no | yes | yes | yes |
| Monitoring and Alarms | no | yes | yes | yes |
| Sampling planning and management | no | no | yes | yes |
| Data Retrieval from Analytical Devices | no | yes | yes | yes |
| Interactive Data Analysis | no | yes | yes | yes |
| Performance Analysis | no | yes | yes | yes |
| Automatic report generation | no | yes | yes | yes |
| 21 CFR part 11 compliant | no | optional | optional | optional |
| GAMP compliant | yes | yes | yes | yes |
| ISA S88 standard | yes | yes | yes | yes |
| Password protection | no | no | yes | yes |
| User definable access rights | no | yes | yes | yes |
| Remote Access | no | yes | yes | yes |
| Interactive Synoptic | no | yes | yes | yes |
| Data management | ||||
| Data storage system | Oracle database | Oracle database | Oracle database | Oracle database |
| Minimum sampling frequency | 1 second | 1 second | 1 second | 1 second |
| Sample frequency selectable per parameter | yes | yes | yes | yes |
| Data reduction definable per parameter | yes | yes | yes | yes |
| Data export to Excel | yes | yes | yes | yes |
| Data export in ASCII format | yes | yes | yes | yes |
| Graph export in graphics format | yes | yes | yes | yes |
| Dynamic Data Link to other programs | no | yes | yes | yes |
| On-line calculations using on-line and off-line data |
no | yes | yes | yes |
| Data display | ||||
| Line graphs | yes | yes | yes | yes |
| Maximum number of y-axes per graph | 8 | 8 | 8 | 8 |
| Synoptic (P&I diagram) | no | yes | yes | yes |
| Procedure flow chart | no | yes | yes | yes |
| Combination of current and historic data in graphs |
yes | yes | yes | yes |
| Combination of different active batches in graphs |
yes | yes | yes | yes |
| Measured data table display | yes | yes | yes | yes |
| Scatter plots | yes | yes | yes | yes |
| Storage of predefined graph settings | yes | yes | yes | yes |
| Supervisory control | ||||
| Programming of time based actions | no | yes | yes | yes |
| Programming of event based actions | no | yes | yes | yes |
| Profiling of setpoints | no | yes | yes | yes |
| Manual setting of local control setpoints | no | yes | yes | yes |
| Recipe definition | no | yes | yes | yes |
| Other | ||||
| Notebook for process and equipment remarks |
yes | yes | yes | yes |
| Event viewer for system comments | yes | yes | yes | yes |
| Audit trail | no | optional | optional | optional |
Lucullus® PIMS is ideal for the following applications:
- Microbial and cell culture
- Batch
- Fed-Batch
- Perfusion
- Continuous cultivation
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