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Livit ACE
Continuous adherent cell culture platform
- Significantly reduce COGS
- Reduce development timelines and costs
- Eliminate the need to adapt naturally adherent cells
- Reduce capital cost and footprint requirement through improved productivity
A collaborative breakthrough solution
Livit ACE combines the best of CellRev's proprietary processing technologies with Getinge's bioprocessing expertise and equipment into one integrated cell manufacturing solution.
Livit ACE is a complete package providing a novel bioprocessing solution. It is a cost-effective alternative to expensive process development and complex technology selection.
The main equipment in the Livit ACE platform are:
- a Getinge Livit Flex (dual) controller with Livit software
- a Getinge AppliFlex ST single-use or Getinge Applikon multi-use bioreactor
- a Carr Biosystems UFMini®
How it works
1. Cell growth
Cells are seeded and grown in the bioreactor as per any other cell culture process. The target confluence is established during customer trial work.
2. Cell detachment
CellRev's proprietary reagent Continuase™ is added to the culture at a predefined concentration to trigger the release of cells to facilititate further expansion. This patented method enables the controlled detachment of adherent cells from a variety of surfaces. The rate of cell detachment is maintained equal to growth rate to allow steady state operation at high cell densities.
3. Cell collection
Cells are collected continuously for cell banking or downstream processing. This reduces the need for large scale batch harvesting and facilitates optimal downstream design.
Continuous bioprocessing
Continuous cell processing poses a significant opportunity for cellular product developers to improve cost, process stability, and consistency of products. It eliminates manual handling and thus human error.
One integrated solution
Livit ACE provides a complete process solution including standard application development, equipment, technology transfer, commissioning and training support.
Transferable technology
Livit ACE offers seamless translation from research to production with superior product reproducibility. Steady state operation can be replicated every run, thus providing a robust upstream process.
Livit ACE is ideal for the following applications:
- Cell-based vaccines
- Cell therapies
- Cellular agriculture
- Continuous cultivation
- Process intensification