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Applikon BioPilot

Biorreactor de esterilización in situ para la producción a pequeña escala

El Applikon BioPilot multiusos es el primer paso hacia la producción de bioprocesos. El BioPilot se escala de forma lineal a partir de biorreactores a escala de laboratorio, lo que simplifica la transferencia a la producción, lo que a su vez se traduce en un tiempo de comercialización más rápido. El concepto coherente de modularidad, mediante el uso de módulos estándar para construir el biorreactor, simplifica la personalización para cumplir con cualquier requisito específico de cultivos microbianos y celulares.

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Your interest in bioreactor systems

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

The BioPilot stainless steel bioreactor system on skid

Modelo de escalado preciso para la producción

  • El diseño compacto reduce el espacio necesario en el suelo
  • El diseño conforme con las cGMP simplifica la validación
  • El diseño modular permite una configuración sencilla para satisfacer las demandas del proceso
  • Funcionamiento sin preocupaciones al minimizar los errores humanos
 

Esenciales en el desarrollo de vacunas y medicamentos

Los biorreactores desempeñan un papel clave en el desarrollo y la producción de vacunas y medicamentos que salvan vidas. Este complejo proceso requiere sistemas altamente optimizados y de última generación. Con los diseños estandarizados del biorreactor Applikon BioPilot, proporcionamos facilidad y flexibilidad a la hora de personalizar el recipiente para hacer frente a cualquier tipo de necesidad de aplicación con componentes estándar.

Vea el vídeo para descubrir los biorreactores de acero inoxidable que se utilizan en los bioprocesos.

Validación sencilla

La gama BioPilot se ha construido conforme a los estándares más recientes de procesamiento higiénico, cumple con los requisitos de cGMP y GAMP y se puede suministrar con un amplio paquete de documentación para facilitar una validación eficiente.

Manejo sencillo

Los biorreactores de acero inoxidable minimizan el riesgo de contaminación, ya que no hay que sustituir consumibles en cada ciclo. Además, estos biorreactores esterilizables in situ se suministran con conexiones de agitador de acoplamiento magnético. Mientras que el eje del agitador continúa desde el exterior hasta el interior del biorreactor con conexiones tradicionales (junta mecánica doble o con sello de labios), en este caso la conexión se establece mediante imanes. Dado que no hay conexión con el mundo exterior, no hay riesgo de contaminación.

La construcción de bastidor abierto ofrece un fácil acceso para el mantenimiento y el funcionamiento.

Limpieza sencilla

La gama de biorreactores de acero inoxidable Applikon se fabrica completamente con acero inoxidable 316L de grado farmacéutico y se suministra con un acabado de superficie de Ra <0,4 micras. Esta superficie lisa garantiza que las biopelículas y los residuos no se adhieran a los componentes internos de los biorreactores. Esto simplifica en gran medida el procedimiento de limpieza y aporta tranquilidad, ya que sabe que los biorreactores siempre estarán limpios gracias a un proceso reproducible.

Especificaciones técnicas

  Volumen total (litros) Volumen de trabajo (litros) Volumen de trabajo mínimo (litros) Relación de aspecto del volumen total Relación de aspecto del volumen de trabajo
Celda piloto de 30 litros 30 20 7 1,5 1,0
Celda piloto de 60 litros 60 40 10 1,5 1,0
Celda piloto de 130 litros 130 100 21 1,5 1,0
Piloto microbiano de 40 litros 40 34 9 3,0 2,4
Piloto microbiano de 70 litros 70 50 13 3,0 2,2
Piloto microbiano de 140 litros 140 100 20 3,0 2,2
Piloto microbiano de 270 litros 270 200 40 3,0 2,2
Sistema de accionamiento Agitador de acoplamiento magnético montado en la parte superior o inferior para cultivos microbianos y montado en la parte superior para sistemas de cultivo celular
Velocidad periférica máxima del agitador (m/s) 3 m/s para cultivos microbianos y 1 m/s para cultivos celulares
Impulsores Rushton y marinos con diámetros exteriores de 0,3-0,5 de recipiente
Rociador de gas Rociador poroso, rociador L-Sparger o rociador tipo anillo
Superposición de gases Conducto de superposición de gases
Gases de escape Condensador de gases de escape refrigerado por agua con espiral interna y/o camisa
Muestreo Sistema de muestras reesterilizable opcional en puerto DN25 en pared lateral inferior
Drenaje Drenaje con fuelles reesterilizables montados en la parte inferior
Adiciones Adiciones esterilizables (válvulas de empuje) y puertos adicionales reesterilizables
pH Medición: Sensor de pH clásico de 12 mm en puerto DN25 en la pared lateral inferior
  Control: mediante una bomba de ácido o gas CO2 (rotámetro o MFC) en combinación con una bomba de álcali
DO2 Medición: sensor polarográfico de DO2 de 12 mm en puerto DN25 en la pared lateral inferior
  Control: mediante una combinación de N2, aire, O2 (rotámetro o MFC) y agitación
Temperatura Medición: sensor Pt-100 en puerto DN25 en pared lateral inferior
  Control de cultivo: camisa de refrigeración y calefacción a través de la pared del biorreactor
Espuma Medición: sensor de espuma de altura regulable con conductividad
  Control: a través de la bomba antiespumante
Nivel Medición: Sensor de nivel de altura regulable basado en la conductividad o células de carga en el bastidor del biorreactor
  Control: bomba para la adición o eliminación de líquido