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Applikon AppliSens 传感器

生物工艺的准确测量

在生物技术和制药行业，准确掌握有关生物工艺的工艺值信息至关重要。此类数值会直接影响细胞的活力、生产率和稳定性，同时还可能影响活性成分的分析。AppliSens 传感器是专为生物工艺中的长期、稳定和准确测量而设计的。

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若您想了解生物反应器系统

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Sotelab
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Sotelab
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AP Bioprocess
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AP Bioprocess
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Intek Group
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Colombia

Intek Group
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Vekamaf
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Holm & Halby
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Denmark

Holm & Halby
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Estonia

Bio Techa
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Estonia

Bio Techa
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Hungary

Holimex
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Hungary

Holimex
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India

Spinco Biotech Pvt. Ltd.
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India

Spinco Biotech Pvt. Ltd.
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Indonesia

PT Arico Sainsindo Nusantara
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Indonesia

PT Arico Sainsindo Nusantara
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Ireland

Asistec
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Asistec
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Medent Group
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Italy

Steroglass
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Steroglass
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Bio Techa
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Bio Techa
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Norway

Bio Nordica
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Norway

Bio Nordica
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Labo Baza
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Russia

Abtek
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Abtek
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Singapore

Zil Sci Pte. Ltd.
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Zil Sci Pte. Ltd.
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Seperations
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South Africa

Seperations
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South Korea

SeouLin Bioscience
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South Korea

SeouLin Bioscience
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Switzerland

Resea Biotec
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Switzerland

Resea Biotec
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Taiwan

Tseng Hsiang Life Science Ltd.
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Taiwan

Tseng Hsiang Life Science Ltd.
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Meditop Co., Ltd

Holm & Halby
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Meditop Co., Ltd

Holm & Halby
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Turkey

Ant Teknik
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Turkey

Ant Teknik
Phone: +90 216 422 6700
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AppliSens DO2 sensors to measure dissolved oxygen concentration in bioprocesses
Applikon bioreactor headplate with AppliSens sensors for bioprocess analytics
AppliSens pH sensors to measure the pH value in cultivation processes

持续测量参数，实现过程优化和产品产量大幅度提升

  • 保持信号长期稳定
  • 易于校准，响应时间短
  • 对结垢不敏感，不易导致漂移

生物过程的正确控制需要对许多过程参数进行可靠的监控。从基本的物理化学性质，如 pH 值或溶解氧，到测定生物量密度或代谢物浓度，Getinge 提供多种过程分析技术 (PAT)，帮助您完成复杂的测量过程。

The optical DO sensor LumiSens for bioprocess analytics

光学 DO 传感器：LumiSens

  • 降低维护成本
  • 采用两部分设计，传感器的使用寿命更长
  • 高压灭菌后可直接使用，无需极化处理

Applikon LumiSens 传感器可在高压灭菌后立即投入使用。与传统极谱法 DO2 传感器相比，本款设备不再需要极化，显著减少了校准需求：每年仅需校准一次，无需每次运行时均进行校准。电解液和薄膜无需更换，从而降低维护成本。RedFlash 光学技术可实现准确测量，特别适用于传统探头无法准确测量的低氧浓度范围。智能传感器在设计上将电子元件与玻璃传感器部件加以分离，从而确保传感器即使经过重复灭菌仍具有较长的使用寿命。

AppliSens DO2 sensors

DO2 传感器

  • 易于校准
  • 使用钛合金和 PEEK 材料，漂移小
  • 采用全电抛光表面，确保易于清洁

在生物技术过程中，测定溶解氧（即 DO2）是过程优化和产品产出最大化的基础。在调节总体新陈代谢的过程中，微生物或细胞会对氧气浓度做出反应。因此，了解 DO2 浓度并在工艺中对其进行适当控制至关重要。AppliSens DO2 传感器是专为生物工艺中的长期、稳定和准确测量而设计的。DO2 传感器带有钛膜模块，可尽可能地减少测量漂移。

AppliSens pH sensors

pH 传感器

  • 准确测量
  • 保持信号长期稳定
  • 套管隔膜使得设备对结垢不敏感，不易导致漂移。

在上游生物工艺中，掌握有关生物工艺的 pH 值信息至关重要。pH 值会直接影响细胞的活力、生产率和稳定性，同时还可能影响活性成分的分析。AppliSens pH+ 电极配备固定套管隔膜，可减少培养基对 pH 测量的影响。与传统隔膜类型相比，本款套管隔膜提高了测量精度和传感器的使用寿命，而这对于长期持续的生物技术培养过程至关重要。

Two RedOx sensors for the Applikon multi-use bioreactor

氧化还原传感器

  • 准确测量
  • 响应时间短
  • 保持信号长期稳定



生物反应器培养物的氧化还原电位（还原/氧化）可用氧化还原传感器测量。传感器的读数取决于 pH、生长阶段、生长培养基成分和发酵终产物（尤其是发酵酸和氢）。此外，由于溶解氧传感器在厌氧情况下无法提供过多的工艺信息，因此 RedOx 测量还可以在厌氧发酵环节中用作该传感器的替代方案。

符合 cGMP 应用要求

AppliSens 传感器由经 FDA 批准的材料组成，符合 cGMP 要求。此设备可经受重复性的原位灭菌 (SIP) 和原位清洁 (CIP) 循环。

传感器及传感头设计紧凑

AppliSens 传感器采用钢化玻璃轴，坚固耐用。传感头在生物反应器罐盖上占用空间小，易于安装。

可与其他品牌相互替换

AppliSens 传感器配有 PG 13.5 标准化连接，可确保与其他品牌的生物反应器互换。自由选择。

LumiSens 光学 DO 传感器规格

物理特性  
直径 (mm) 8
插入长度 (mm) 115, 135, 185
电缆连接 USB-A
适用温度范围 0 – 70 °C
测量范围 0-250%（空气），0-50%（氧气）
玻璃管使用寿命 最少 20 次高压灭菌循环
测量原理 光学
传感器连接 电磁
信号 数字

 

DO2 传感器规格

物理特性  
直径 (mm) 12
插入长度 (mm) 70, 110, 235, 325, 425, 590
小型生物反应器直径 (mm) 8
小型生物反应器插入长度 (mm) 150, 170
传感器连接 K9
信号 模拟 nA
漂移 每周 <2%

 

pH 传感器规格

物理特性  
直径 (mm) 12
长度 (mm) 120, 235, 325, 425, 590
小型生物反应器直径 (mm) 8
小型生物反应器长度 (mm) 115, 135, 185
传感器连接 K9
通信类型 模拟 mV
测量范围 (pH) 0 - 12

氧化还原传感器规格

物理特性  
直径 (mm) 12
长度 (mm) 120, 235, 325
小型生物反应器直径 (mm) 8
小型生物反应器长度 (mm) 115, 135, 185
传感器连接 K9
通信类型 模拟 mV

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