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Applikon BioSep

Perfusão de cultura celular dimensionável

O Applikon BioSep é um dispositivo de retenção de células exclusivo para o processo de alimentação constante de meios frescos e remoção de meios gastos, mantendo um alto número de células viáveis. Ele usa ondas ultrassônicas ressonantes de alta frequência para separar as células e, dessa forma, remover automaticamente os detritos celulares, o que o torna a solução perfeita para bioprocessos contínuos.

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Your interest in bioreactor systems

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.  

Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

The Applikon BioSep 50 liter perfusion device
The Applikon BioSep 10 liter perfusion device
The Applikon BioSep 1 liter perfusion device
Applikon BioSep

A solução ideal para cultivo de longo prazo

  • Remoção automática de detritos da célula
  • Sem danos às células
  • Sem contaminações ou bloqueios, o que permite uma operação de longo prazo
  • Dispositivo de perfusão dimensionável (0,1 a 1.000 L/dia)

Alta eficiência de separação

Usar a tecnologia de ressonância acústica permite uma alta eficiência de separação (99%) sem danificar nenhuma célula. Um modo de operação padrão emprega, por exemplo, uma bomba de coleta na porta de saída da câmara do ressonador e uma bomba de recirculação para o retorno de células separadas que se depositaram a partir do campo de energia acústica dentro da câmara do ressonador. Como alternativa, o sistema Applikon BioSep pode ser configurado para permitir uma operação semicontínua ou estratégias alternativas de recirculação celular.

Fácil instalação e operação

O Applikon BioSep pode ser montado diretamente na placa superior do biorreator. Uma caracterização abrangente tem dimensionabilidade total comprovada entre os diferentes tamanhos, permitindo que você comece no modo de perfusão diretamente no início da otimização do processo até a produção.
O sistema Applikon BioSep está disponível em 1 L/dia, 10 L/dia, 50 L/dia, 200 L/dia e 1.000 L/dia e é compatível com biorreatores de qualquer marca.

Comprovado em condições de cGMP

O sistema Applikon BioSep é usado como dispositivo de perfusão em vários processos cGMP operados comercialmente. Por padrão, os modelos de separação de 50 L/dia e 200 L/dia são fornecidos com toda a documentação e serviços necessários para a operação cGMP.

Especificações

Sistema BioSep 1L 10L 50L 200L 1000L
Taxa máxima de perfusão 1 L/dia 7 L/dia 45 L/dia 200 L/dia 1.000 L/dia
Taxa mínima de perfusão 0,1 L/dia    0,7 L/dia 4,5 L/dia 20 L/dia 100 L/dia
Eficiência de separação Até 99% (dependendo da concentração celular e do fluxo de perfusão)
Concentração celular mínima 2 x 105 células/mL (dependendo do tamanho da célula)
Conexão do biorreator Tubo com DE de 6 mm Tubo com DE de 12 mm Montado separadamente Montado separadamente Montado separadamente
Entrada do meio Conexão de mangueira de 3 mm Conexão de mangueira de 6 mm Conexão de mangueira de 10 mm 0,5” TC 0,5” TC
Linha de retorno para o biorreator Conexão de mangueira de 3 mm Tubo de imersão com DE de 6 mm 0,5” TC 0,5” TC 0,5” TC
Saída de perfusão Conexão de mangueira de 3 mm Conexão de mangueira de 6 mm Conexão de mangueira de 6 mm 0,5” TC 0,5” TC
Peso 0,1 kg 0,5 kg 1,5 kg 13 kg 70 kg
Volume do ressonador 0,7 mL 7 mL 50 mL 290 mL 1.450 mL
           
Controlador BioSep APS 995 APS 990 APS 990 APS 992 APS 993
Potência do controlador BioSep 15 Watts 150 Watts 150 Watts 350 Watts 1.500 Watts

Dimensões do controlador BioSep

(PxLxA, mm)

Combinado com o my-Control 305 x 130 x 130 305 x 130 x 130 450 x 400 x 135 450 x 300 x 450
Peso do controlador BioSep (kg) Combinado com o my-Control 3,5 3,5 17,6 43